Sindh Medical College (SMC), is a medical college situated beside Jinnah Postgraduate Medical Centre, in Karachi, Sindh, Pakistan.
SMC started functioning on April 7, 1973 after the final decision of a committee constituted by the Government of Sindh and after its budget was approved in the first week of March 1973. Its first group of students, numbering about two hundred, was admitted to its first year MBBS class in the College for the 1972-73 session, with the late Professor Dr. Khawaja Moin Ahmd as its Project Director and First Principal.
In the beginning the College operated in a building of the paediatrics ward of the Jinnah Postgraduate Medical Centre. This building was actually an army barracks constructed in the year 1865 and transferred to the Jinnah Postgraduate Medical Centre in 1959. In the beginning, there were three departments: anatomy (including histology), physiology, and biochemistry. In later years, a new academic block was constructed to house the departments of pathology, pharmacology, forensic medicine, and community medicine. This complex was equipped with modern audiovisual technology. It also housed new laboratories and museums, as well as administrative offices.
The old barracks has been renovated to house a new faculty of SMC, under the name of Dr. Ishrat ul Ebad Khan Institute of Oral Health Sciences. The Sindh Medical College campus now houses a complete dental hospital and school of dental medicine plus post graduate institute.
Since the foundation of the College in 1973, a boys' hostel has been organized and a building for a girls' hostel has been purchased by the PECHS.
The college is completely associated with the Jinnah Postgraduate Medical Centre, the National Institute of Child Health, and the National Institute of Cardiovascular Diseases.
In 2003, SMC became a part of the Dow University of Health Sciences. It shares curriculum, faculty, and other resources with the other affiliated institutions of DUHS, namely DMC (Dow Medical College) and DIMC (Dow International Medical College). The former head of the physiology department at SMC is now the dean of DIMC.